Brown Seaweed In the article, the authors discussed the topic of energy and media savings in a public transport company.The article is of a review nature, referring to 100 sources, including scientific papers, books, conference proceedings, and websites.In the first part, a detailed literature review on environmental protection problems in road tra
In vivo Bio-Distribution and Toxicity Evaluation of Polymeric and Lipid-Based Nanoparticles: A Potential Approach for Chronic Diseases Treatment
João Fonseca-Gomes,1,2,* Joana A Loureiro,3,* Sara R Tanqueiro,1,2 Francisco M Mouro,1,2 Pedro Ruivo,2 Tânia Carvalho,2 Ana M Sebastião,1,2 Maria José Diógenes,1,2,* Maria Carmo Pereira1– 3,* 1Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, Lisboa 1649-028, Port
Genome-Wide Identification and Gene Expression Analysis of the OTU DUB Family in Oryza sativa
Ovarian tumor domain (OTU)-containing deubiquitinating enzymes (DUBs) are an essential DUB to maintain protein stability in plants and play important roles in plant growth development and stress response.However, there is little genome-wide identification and analysis of the OTU gene family in rice.In this study, CHAMOMILE SHAMPOO we identified 20
Cyclosporin A-Based PROTACs Can Deplete Abundant Cellular Cyclophilin A without Suppressing T Cell Activation
Cyclophilin A (CypA), the cellular receptor of the immunosuppressant cyclosporin A (CsA), is an abundant cytosolic protein and is involved in a variety of diseases.For example, CypA supports cancer proliferation and mediates viral infections, such as the human immunodeficiency virus 1 (HIV-1).Here, we present the design of PROTAC (proteolysis targe